Some huge games are set up for the weekend, including Auburn and Mississippi State, as well as the Red River Rivalry, Mississippi and Texas A&M; as well as USC at Arizona.
| Thu, Oct 9, 2025 | Time (ET) | TV |
| Brigham Young @ UCF | 7:30 PM | ESPN |
| Fri, Oct 10, 2025 | Time (ET) | TV |
| Washington State @ (25) Stanford | 9:00 PM | ESPN |
| San Diego State @ New Mexico | 9:30 PM | ESPNU |
| Fresno State @ UNLV | 10:00 PM | CBSS |
| Sat, Oct 11, 2025 | Time (ET) | TV |
| Rice @ Army | 12:00 PM | |
| Louisiana-Monroe @ Kentucky | 12:00 PM | SECN |
| Cincinnati @ Miami (FL) | 12:00 PM | ESPN3/ESPNGP |
| (1) Florida State @ Syracuse | 12:00 PM | ESPN |
| Indiana @ Iowa | 12:00 PM | ESPNU |
| Northwestern @ Minnesota | 12:00 PM | BTN/BTN2 |
| (13) Georgia @ (23) Missouri | 12:00 PM | CBS |
| West Virginia @ Texas Tech | 12:00 PM | FS1 |
| Illinois @ Wisconsin | 12:00 PM | ESPN2 |
| Middle Tennessee @ Marshall | 12:00 PM | FSN |
| Tulsa @ Temple | 12:00 PM | ESPNN |
| Texas @ (11) Oklahoma | 12:00 PM | ABC/ESPN3 |
| Duke @ (22) Georgia Tech | 12:30 PM | ESPN3/ESPNGP |
| Buffalo @ Eastern Michigan | 1:00 PM | ESPN3 |
| Miami (OH) @ Akron | 2:00 PM | ESPN3 |
| Massachusetts @ Kent State | 2:00 PM | ESPN3 |
| Bowling Green @ Ohio | 2:00 PM | ESPN3 |
| Arkansas State @ Georgia State | 2:00 PM | ESPN3 |
| Western Michigan @ Ball State | 3:00 PM | ESPN3 |
| New Mexico State @ Troy | 3:00 PM | ESPN3 |
| Louisville @ Clemson | 3:30 PM | ESPNU |
| Virginia Military @ Navy | 3:30 PM | CBSS |
| Boston College @ North Carolina State | 3:30 PM | ESPN3/ESPNGP |
| North Carolina @ (6) Notre Dame | 3:30 PM | NBC |
| (8) Michigan State @ Purdue | 3:30 PM | ABC/ESPN2 |
| (9) TCU @ (5) Baylor | 3:30 PM | ABC/ESPN2 |
| Toledo @ Iowa State | 3:30 PM | IAST |
| (2) Auburn @ (3) Mississippi State | 3:30 PM | CBS |
| (12) Oregon @ (18) UCLA | 3:30 PM | FOX |
| North Texas @ UAB | 3:30 PM | AMSN |
| Liberty @ Appalachian State | 3:30 PM | ESPN3 |
| Chattanooga @ Tennessee | 4:00 PM | SECN |
| (16) Oklahoma State @ Kansas | 4:00 PM | FS1 |
| Central Michigan @ Northern Illinois | 5:00 PM | ESPN3 |
| (7) Alabama @ Arkansas | 6:00 PM | ESPN |
| Washington @ California | 6:00 PM | PAC12 |
| Idaho @ Georgia Southern | 6:00 PM | ESPN3/ESPNGP |
| Penn State @ Michigan | 7:00 PM | ESPN2 |
| FIU @ Texas-San Antonio | 7:00 PM | FCS |
| (19) East Carolina @ South Florida | 7:00 PM | ESPNU |
| Houston @ Memphis | 7:00 PM | CBSS |
| LSU @ Florida | 7:30 PM | SECN |
| Charleston Southern @ Vanderbilt | 7:30 PM | ESPN3/ESPNGP |
| Old Dominion @ UTEP | 8:00 PM | AMSN |
| Connecticut @ Tulane | 8:00 PM | ESPNN |
| (3) Mississippi @ (14) Texas A&M; | 9:00 PM | ESPN |
| Air Force @ Utah State | 10:15 PM | ESPNU |
| USC @ (10) Arizona | 10:30 PM | ESPN2 |
| Colorado State @ Nevada | 10:30 PM | CBSS |
| Wyoming @ Hawaii | 11:59 PM |
